![]() People with the disorder lead normal, healthy lives. Gilbert’s syndrome is a mild disorder that typically doesn’t need medical treatment. In other cases, Gilbert’s syndrome may be accompanied by symptoms similar to more serious liver diseases, so thorough medical investigation is needed.Ī genetic test exists that can detect the gene that causes Gilbert’s syndrome, but this is not usually necessary for a diagnosis and is not widely available. It is often diagnosed by accident when blood tests are ordered to investigate an unrelated condition. In many cases, Gilbert’s syndrome is so mild that there are no obvious symptoms. In a person with Gilbert’s syndrome, the bilirubin levels typically fluctuate and only sometimes hover within the normal range. This leads to greater than normal levels of bilirubin circulating in the bloodstream, which can cause yellowing of the skin and eyes. Gilbert’s syndrome occurs due to the reduced activity of a liver enzyme that makes the liver less capable of processing bilirubin. Further processing of bilirubin happens within the liver. It is created by the breakdown of old red blood cells by the spleen. Processing bilirubinīilirubin is the yellowish-brown pigment that gives bile its colour. A person with hepatitis will usually have dark urine and may also have a fever. A person with Gilbert’s syndrome has normal (straw-coloured) urine. Gilbert’s syndrome is not related to viral hepatitis, which also causes jaundice. However, it is not clear that these symptoms are directly related to higher levels of bilirubin. Other symptoms are sometimes reported, including: Gilbert’s syndrome typically has no obvious symptoms, other than yellowing of the skin or eyes (jaundice). Gilbert’s syndrome is considered a harmless condition and typically does not need treatment. Usually, the disorder is diagnosed by chance during the investigation of unrelated illnesses. Men are at higher risk than women and tend to develop Gilbert’s syndrome between their late teens and early 30s. Gilbert’s syndrome is a common, mild disorder thought to be inherited in around half of all cases. Despite the person’s jaundiced appearance, the functioning of their liver is normal. ![]() ![]() This leads to high levels of bilirubin in the bloodstream, which can cause the skin and eyes to turn yellow (jaundice). In a person with Gilbert’s syndrome, the liver is unable to consistently process the yellowish–brown pigment in bile, called bilirubin. breaks down fats using bile stored in the gall bladder.filters impurities and toxins from the body.
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